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These distinct mechanisms highlight why both approaches can be complementary in combating oxidative stresshydrogen water provides immediate protection against the most damaging free radicals, while GR ensures long-term maintenance of the glutathione antioxidant system

In cardiomyocytes, the high NAD+ level may co-exist with the ATP/O2 coupling [19]

This conclusion can be supported by our observations that nave and CM subsets are less susceptible ferroptosis, while EM and TEMRA cells are more sensitive to this type of death

For instance, the Nupr1/Chop pathway is an endoplasmic reticulum stress pathway that mediates apoptosis

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