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Moreover, in meta-analysis was shown that genetic variants in the genes encoding GSTs may not only play a role in the development of CML, but also affect the response of patients to tyrosine kinase inhibitor (TKI) treatment

Indeed, PC-phospholipase C expression on the NK cell membrane correlates closely with CD16 receptor expression, suggesting a potential relationship between enzyme externalization, NK cell maturation, and CD16-mediated cytolytic process (134)