Some studies in IBD diseases have proposed the immunomodulatory function of nicotine on Th1/Th2 toward Th1, which is perhaps mediated via mir-124-IL6R signaling
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Further, the guidance states that NRT drug products that have demonstrated effectiveness for cessation or reduction in risk of relapse may include information in the labeling regarding how quitting smoking can lower a persons chances of having lung disease, heart disease, and the risk of getting certain types of cancer that are related to smoking, without providing additional data
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