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doi: 10.1093/jn/108.5.773 34 AsanoARomanHBHirschbergerLLUshiyamaANelsonJLHinchmanMMet al

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214,215,216,217 Additionally, sensory neurons in the dorsal root ganglia (DRG) exhibit altered phenotypes, such as reduced neurofilament synthesis, endoplasmic reticulum stress, and changes in key plasticity molecules, such as growth-associated protein 43 (GAP43) and heat shock proteins, leading to mitochondrial dysfunction and loss of peripheral nerve function

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Omega oxidation yields toxic metabolites: 2-propyl-2-pentenoic acid (2-EN-VPA) may cause cerebral edema