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In vivo studies reported a 15-fold increase in brain DA levels compared to free DA administration, restoring dopaminergic function and reducing oxidative stress in PD models

A lower dose is not automatically ineffective

Fauci, M.D

Jiang Y, Sang W, Wang C, Lu H, Zhang T, Wang Z, et al

the ligand preferably is a ligand for a glutathione transporter of a vertebrate target cell, more preferably a glutathione transporter of a mammalian target cell, and most preferably a glutathione transporter of a human target cell