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Whether parallel alteration in platelet responsiveness and long-term thrombosis risk occurs in subjects remains to be determined, but as noted above, elevated serum levels of carnitine are associated with enhanced risks of major adverse cardiovascular events (6)

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Common challenges for any systematic review of studies investigating autism spectrum disorders include changes in the criteria for diagnosis and laboratory methodology, the emphasis of early studies on individual metabolites rather than metabolic systems (e.g

doi: 10.1210/endrev/bnae019 26 WolffJChaikoffIL

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