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The idea is not to "correct," but to support measurable skin quality (hydration, elasticity) in a progressive approach, as clinical trials do over several weeks

However, cell culture conditions may not accurately reflect nutrient availability and uptake in the host tissue

Also, its repertoire of protein disulphide isomerase (PDI), thioredoxin and glutaredoxin is limited as compared to its other eukaryotic counterparts 10,11