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Acta Haematologica 145:244256 Cutrona G, Tripodo C, Matis S, Recchia AG, Massucco C, Fabbi M, Colombo M, Emionite L, Sangaletti S, Gulino A, Reverberi D (2018) Microenvironmental regulation of the IL-23R/IL-23 axis overrides chronic lymphocytic leukemia indolence

Kinoshita K, Ozaki N, Takagi Y, et al

Common biological features of chronic injury Microvascular limitation: the tissue is under-perfused, which slows nutrient delivery and waste removal Inflammatory persistence: cytokine signaling stays elevated and disrupts remodeling Disorganized collagen: collagen exists, but it is poorly aligned, weak, or prone to reinjury Mechanical mismatch: loads exceed tissue capacity due to weakness, compensation, or instability Neurogenic sensitivity: irritated tissues and nerves amplify pain signals even when imaging is normal In other words, chronic injuries do not usually need one intervention

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