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Treatment & Results: After intratympanic PRP therapy , the patient reported: A 2030 % reduction in tinnitus intensity Improved hearing thresholds (10 dB+) in low-to-mid frequencies (500 Hz2000 Hz) Enhanced clarity and reduced need for high television volume Follow-up audiograms continue to show sustained improvements

114 KurokawaS.TakehashiM.TanakaH.MiharaH.KuriharaT.TanakaS.et al (2011)

Injections were administered intraperitoneally once per day, the first application was given 30 min after ligature placement, while the final application 24 h before the tissue harvest

The PCA was conducted using the FactoMineR package (52) in R, with the first five principal components capturing the primary sources of variation in the data

Although the mechanisms that enable GPX4 expression or degradation in response to drug treatment are well understood, much more is to be learned of the complex regulatory processes that control GPX4 levels during pathological conditions