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S-nitrosylation of EAAT2 causes a decrease in transporter uptake of glutamate and an increase in glutamate in the synapse

These N-terminal sequences are attained by alternative usage of three translational initiation sites (AUGs) that reside in two alternative exons 1 (exon 1a and 1b)

[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Fields M., Marcuzzi A., Gonelli A., Celeghini C., Maximova N., Rimondi E

The ideal target should be expressed mainly, if not exclusively, on MB cells but not on healthy cells

Again, this impairment is effectively bypassed by supplementation with gamma-glutamylcysteine, which can be transported into cells where it will be rapidly converted to GSH by GSH synthase