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The explanation for this discrepancy can be found in recent papers showing that some cancer cell linesincluding HCT116are not affected by L-BSO or GSH synthesis inactivation because they can compensate GSH depletion by the thioredoxin (TXN) pathway 25 , and by maintaining protein homeostasis through deubiquitinating enzymes (DUB) 32

It is unknown if MHDs impact post-transplant health-related quality of life (HRQOL), a patient-centered outcome important to LT survivors

Glutathione has a documented safety profile in the clinical literature

Some approaches include: BCL-2/BCL-xL inhibitors (e.g., navitoclax), tyrosine kinase inhibitors, metabolic stressors, or even immune-based clearance

To prevent bias, these morphometric measurements were conducted blindly for images of 10 fields per section for 8 rats per group (HPF, 400)