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At the top dose (675 mg/kg), relative kidney weights were slightly increased in males, urinary production was decreased, and there were variations in serum biochemistry, most of which were attributable to reduced water intake

Recently, a genetic screen revealed two lipid metabolism regulatorslysophosphatidylcholine acyltransferase 3 (LPCAT3) and acyl-CoA synthetase long-chain family member 4 (ACSL4)that drive ferroptosis via an accumulation of oxidized phospholipids in the cell membrane [40]

Aberrant glucose metabolism is a characteristic of cancer and the TME produces metabolic challenges to T cells, thus impairing the antitumor immune response [45]

Glutamine is critical for maintaining the cFLIP level To gain mechanistic insight into the increased TRAIL sensitivity caused by Gln deprivation, we explored the effect of Gln deprivation on the factors involved in the TRAIL-mediated extrinsic pathway of apoptosis

Beta-glucuronidase, an enzyme produced by the gut microbiome, can reverse the reaction that the UGT enzymes did to make the estrogen metabolites more water-soluble