For detection, SuperSignal West Femto Maximum Sensitivity Substrate (Thermo Scientific) was used as the chemiluminescence substrate and ImageQuant LAS 4000 mini (GE Healthcare) was used for imaging
Elastin and collagen fibres in cutaneous wound healing
Ginsenoside Rg1 improves Alzheimers disease by regulating oxidative stress, apoptosis, and neuroinflammation through Wnt/GSK-3/-catenin signaling pathway
The antibody-drug conjugate according to claim 1, wherein D is a moiety of formula (IV)WhereinX is C or N, preferably N;Ring A is a heterocycloalkyl having 3 to 10 ring atoms, or a heteroaryl having 5 to 10 ring atoms, said heterocycloalkyl and heteroaryl being optionally substituted, preferably by one or more substituent selected from -OH, =O, C 1 -C 12 alkyl, C 1 -C 12 heteroalkyl, C 3 -C 6 cycloalkyl, heterocyclyl having 5 to 10 ring atoms, aryl having 6 to 10 ring atoms, heteroaryl having 5 to 10 ring atoms, -(C 1 -C 12 alkyl)-(C 3 -C 8 cycloalkyl), -(C 1 -C 12 alkyl)-(heterocycloalkyl having 3 to 10 ring atoms), -(C 1 -C 12 alkyl)-(heteroaryl having 5 to 10 ring atoms), -(C 1 -C 12 alkyl)-(aryl having 6 to 10 ring atoms), and -NR'R"
We have previously shown that OGT expression is increased in tumor tissues from HCC patients