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RIP1Tag2 transgenic mice Expression of the SV40 large T antigen (Tag) under the control of the rat insulin promoter (RIP) causes -cell hyperplasia, which progresses through a series of rate-limiting stages to invasive pancreatic neuroendocrine tumour (PNET)

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Yen explained to MNT: Our preclinical studies suggest that NASH patients who have pernicious anaemia, gastritis, prior gastric bypass surgery, diabetes and taking metformin, or are vegetarians with low folate/B12 intake are several populations that may be at potential risk for worsened NASH