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Piel, 15: 240, 2000

On the other hand, chronic stress promotes a maladaptive shift in adenosine receptors, characterized by the downregulation of A 1 receptors and the upregulation of A 2A receptors in hippocampal glutamatergic terminals [57, 58]

The first study I could find using DSIP for treating withdrawal symptoms was published in 1983: DSIP (25 nmol/kg) was injected intravenously as sole treatment to 67 patients presenting withdrawal symptoms (28 from ethyl alcohol, 39 from opiates)

These findings underscore the potential of melatonin as a valuable supplement in IVM and in vitro growth (IVG) protocols, thereby improving reproductive outcomes