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A higher dose of oral CoQ10, administered at 200 mg twice a day for three months, also seemed to statistically relieve fatigue symptoms in FM patients by approximately 22% [34]

Therefore, the anaplerotic flow between the glutamate-glutamine cycle and the citric acid cycle, mediated by the pyruvate carboxylase enzyme, has been proposed to have detoxification capacities.63 Comparing the susceptibility to morphologic and functional changes of the astroglial and microglial cells under hyperammonemic conditions, astrocytes are more susceptible.64 The capacity of ammonia to free proinflammatory substances on the part of the microglia has also been studied in that context