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Furthermore, research has shown that autophagy-mediated iron death plays a significant role in IPF, with bisphenol A (BPA) enhancing autophagy-mediated ferroptosis through activation of the AMPK/mTOR signaling pathway, thereby exacerbating the progression of IPF [116]

One upstream kinase of eIF2 is general control non-repressor-2 (GCN2), which is activated by free tRNAs in the presence of amino acid deprivation (Scalise et al., 2020)