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Given the difficulty of targeting endothelial cells in the dermis, inhibiting downstream pathways activating melanocytes, like EDN-1/EDN receptor signaling [176,177,178,179], could be particularly relevant for treating melasma and solar lentigo as this signaling pathway is upregulated in these conditions [180]

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The presence of this effector gene results in an incompatible plant-bacterium interaction (resistance)

It serves as a precursor to nitric oxide, a molecule that helps relax blood vessels, promoting improved blood circulation

Although amylase binds to the apical membrane of enterocytes, this localization does not provide any kinetic advantage for starch hydrolysis