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Clinically meaningful responses in insulin-resistant patients typically include a reduction in fasting insulin of 20-40% and an improvement in HOMA-IR within 8-12 weeks at therapeutic doses, though individual variability is wide [1]

Patients should be cautioned that they might experience worsening symptoms during the first 24 to 48 hours, related to a possible steroid flare, which can be treated with ice and NSAIDs

Although these models are valuable for studying amyloid and tau pathology, they do not fully recapitulate the complexity of human AD or the pharmacokinetic behavior of the human BBB (Onos et al., 2016)

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Therefore, NG2-glia may aid neurons and other glia during hyperglycemia