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10.1042/CS20160043 [DOI] [PMC free article] [PubMed] [Google Scholar] Aziz N., Kim M

Moreover, they are more likely to display elevated levels of biomarkers associated with systemic inflammation, such as high-sensitivity C-reactive protein (hs-CRP), fibronectin, TNF-, and IL-8 (144147)

In fact, it has been suggested that reduced exposure to free radicals and increased intake of antioxidant rich foods or antioxidant supplements will enhance the bodys potential to minimize the risk of free radical related health problems.3 Antioxidants such as polyphenols, ascorbic acid, vitamin A, alpha-lipoic acid, thioredoxin, glutathione, melatonin, coenzyme Q, beta carotenoids, alpha-tocopherols as well as antioxidant enzymes including superoxide dismutase, catalase, glutathione-peroxidases , glutathione reductases and glutathione-s-transferases have been widely investigated for the prevention and treatment of diseases resulting from oxidative damage.4, 5, 6, 7 2

6 Core characteristics, distribution, and phenotypic plasticity of microglia 6.1 Microglial heterogeneity, activation signaling, and biphasic regulation in neurodegeneration Microglia, which constitute 1015% of brain cells, play a critical role in the innate immune response and neuroplasticity (Figure 3)