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10.1016/j.redox.2022.102511 81 MamriS.DaoudiN

Common symptoms of lupus include: Chronic fatigue that is not improved by rest Joint pain and swelling , especially in the hands, wrists, and knees Butterfly-shaped rash across the cheeks and nose (malar rash) Photosensitivity , or heightened sensitivity to sunlight Hair loss , often in patches or with overall thinning Low-grade fevers that come and go without infection Chest pain when breathing deeply (pleuritis or pericarditis) Mouth or nose ulcers that dont heal easily Brain fog , memory issues, or difficulty concentrating Anxiety and depression , often linked to inflammation and chronic illness Raynauds phenomenon , where fingers or toes turn white or blue in response to cold or stress Kidney issues or swelling in the legs, ankles, or around the eyes During menopause, the drop in estrogen can increase inflammatory pathways and disrupt immune regulation, potentially leading to lupus flares

doi: 10.1111/his.14884 8 OHaireSFranchiniFKangYJSteinbergJCanfellKDesaiJet al

This combination is studied for synergistic effects on tissue repair, angiogenesis, cell migration, inflammation modulation, and regenerative biology in preclinical models