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The most common example comes from the deficiency of folate and/or vitamin B 12, which would disturb the methylation-dependent pathways by incapacitating a source of methyl groups, a phenomenon that has been linked to mental retardation, psychiatric disorders, myelopathy and neurological diseases [9, 18]

Yanagawa et al

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As expected, since MTT and CTG assays measure cellular metabolism, the CC 50 values of both compounds were somehow lower in the various cell types as compared to growth curve assessment

The prudent approach assumes additive effects are possible in either direction and warrants close monitoring of coagulation parameters