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I have concerns about the new guideline ....I feel there's too much emphasis on treating people with high dose oral B12 and I think this could influence the treatment some people are offered in UK

Immune System Enhancement Vitamin B12 contributes to immune function through several mechanisms: It supports the production of white blood cells, particularly natural killer cells It helps regulate immune system responses It supports cellular energy needed for immune function It contributes to gut health, where much of the immune system resides During periods of increased immune challenge, such as seasonal changes or times of stress, B12 injections can provide valuable support to your body's natural defence mechanisms

[13] Chloramphenicol has been shown to blunt reticulocyte response to cyanocobalamin, while ethanol, colchicine, and nitrous oxide interfere with cobalamin metabolism or utilization, each warranting clinician awareness when evaluating suboptimal treatment outcomes

Make sure the injector has a specific background, has done specific trainings, and practices safe injection habits