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Description

Among metabolic detoxification enzymes, GST is a family of multifunctional enzymes that are ubiquitously present in eukaryotes and prokaryotes, playing an important role in the detoxification of numerous endogenous and exogenous compounds

However, combining the MTH1 inhibitor TH1579 with standard chemotherapy has been shown to induce growth arrest in AML cells and increase intracellular oxidized nucleotides, resulting in significant DNA damage