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in an immunosuppressed person, or in a Se-deficient population), the more viral copies will be generated per unit time, which, applying the multiplier from the basal mutation rate, leads to an increased pool of mutants because of the larger viral population size, thus providing further opportunity for selection of a more fit viral strain (Reference Moya, Elena and Bracho15,Reference Domingo16)

Biochem Biophys Res Commun 612:2229

Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metab 27(3):529547

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Elements such as age, overall health, and any pre-existing deficiencies are key in shaping the protocol