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Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii

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[7377] In elegant work on AAT, Hayashi and coworkers have shown that ground state destabilization occurs in the free enzyme through strain imposed on the internal aldimine, which increases the value of k cat /K M .[24] Additional strain is present in the Michaelis complex with amino acids induced by domain closure