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Overall, parent genes of multiple cognition-associated proteoforms within signalling and scaffolding functional modules are enriched in cell-types with recurrent links to cognitive resilience and frailtySST INs and IT neurons 14,20,21,58,84

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Advances in gene therapy and small molecules able to upregulate EAAT2 expression are under investigation as potential intervention 35 that could mitigate oxidative stress and excitotoxicity, reducing neuronal damage

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While these effects are not evidence of addiction, they do indicate that the brain and nervous system can adapt to long-term SSRI use

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CrossRef Socioeconomic inequalities in the prevalence, non-awareness, non-treatment, and non-control of diabetes among South Korean adults in 2021 Seongju Kim, Dong Jun Kim, Hooyeon Lee, Dong Keon Yon PLOS ONE.2024

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Figure 3 Construction of GSTM1 and GSTT1 knockout mice To further investigate the mechanism by which GSTM1 and GSTT1 are involved in the pathogenesis of acute kidney injury (AKI), we successfully constructed mice with GSTM1 and GSTT1 knockout (GSTM1-KO and GSTT1-KO) using CRISPR-Cas9 technology

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