napqi and glutathione A quantum chemical study of the reactivity of acetaminophen (paracetamol) toxic metabolite N-acetyl-p-benzoquinone imine with deoxyguanosine 5️⃣ Antidote: NAC (N-acetylcysteine) NAC

5 Antidote: NAC (N acetylcysteine) NAC replenishes glutathione, restoring the ability to detoxify NAPQI. It's lifesaving if given early. Example: Hospitals use NAC as the standard treatment for APAP overdose. NAPQI Wikipedia A crossomics analysis of acetaminopheninduced hepatotoxicity in rat liver Sumida 2015 Rapid Communications in Mass Spectrometry Wiley Online Library File:Acetaminophen metabolism.jpg Wikimedia Commons One question. One concept. One point on exam day. Acetaminophen overdose? You should recognize the antidote in seconds, not after rereading a textbook. Train your brain with active recall and build

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