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Hand-Foot Skin Reaction HFSR occurs in 20% of patients treated with sunitinib and is the adverse skin reaction that most frequently leads to the abrupt withdrawal of treatment for skin toxicity.57 In 1 case, HFSR lesions were reported to have been induced by handling a Blackberry device.58 The clinical characteristics and treatment options of sunitinib-associated HSFR lesions59 are similar to those described in the section on the cutaneous side effects of sorafenib, and they will not therefore be repeated in this section

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Medications that are not cytotoxic, such as antituberculosis drugs,30 tamoxifen,31 antibiotics,32 and simvastatin33 have also been blamed