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In addition to such core loop, further key regulators of the circadian clock, such as the nuclear receptors REV-ERB (also known as nuclear receptor subfamily 1, group D, member 1, NR1D1) and REV-ERB (also known as nuclear receptor subfamily 1, group D, member 2, NR1D2) (REV-ERBs), as well as the retinoic acid orphan receptor (ROR) (ROR, ROR, and ROR) establish another feedback loop

For instance, TQ attenuated -synuclein-induced decrease in synaptophysin expression and increase in synaptic vesicle recycling, and thus protected against synaptic toxicity in rat primary hippocampal and hiPSC-derived neurons [57]

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