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Interestingly, even normal metabolic processes, like making energy (ATP), generate oxidative byproducts that deplete glutathione stores

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3 Brain organoids as models to study the role of mitochondria in neurodevelopmental diseases Diseases caused by alterations in mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) have proven challenging to model due to their inherent complexity, particularly the difficulties in manipulating mtDNA (Schon et al., 2020)