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Finally, the pellet (nuclear membranes) was resuspended in the RIPA buffer mentioned earlier and incubated on ice for 30 min

Specifically, AAV-mediated overexpression of the apoE2 variant in the brain reduced amyloid deposition, synaptic loss and microglial overactivation in AD mouse models [233]

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Therefore, ablation of p53 in adipocytes might disrupt the cycle of fat cell apoptosis and LAM recruitment