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So far, it is hypothesized that (1) on-line benefits to stimulation might be the result of directly modulating Purkinje neuron activity, whereas off-line benefits may be the result from long-lasting changes to the activity of Golgi cells [267, 268], and (2) severe cerebellar atrophy with a major loss of neurons above a threshold is unlikely to respond well to non-invasive stimulation

Transdermal bioavailability is estimated at less than 5% for unformulated aqueous solutions

Thiele, A

This peptide reconstitution calculator applies the exact same formula used in pharmaceutical compounding: Dose Concentration = Volume

Considering the non-toxic nature of B12 even in substantial quantities, we believe it is better to err on the side of caution