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In methionine-choline deficient (MCD) diet-induced NAFLD mice, L-carnitine upregulated hepatic PPAR protein expression while inhibiting NF-B p65 activation, thereby attenuating liver inflammation and fibrosis (77)

Also, Escherichia coli , Citrobacter , Klebsiella pneaumoniae , and Shigella , Achromobacter from the strain of Betaproteobacteria , Sporosarcina from Firmicutes , and Actinobacteria have enzymes that can lead to the conversion of all food compounds including choline, betaine, lecithin, gamma-butyrobetaine, ergothioneine and L-carnitine into TMA

Secondly, it was found that dietary Se intake was weakly correlated with peripheral Se levels such as whole blood and serum (84), and the intake of Se did not accurately reflect the relationship of serum Se and thyroid carcinoma, which may be another reason for the inconsistent results of this experiment

Vardiyan R, Ezati D, Anvari M, Ghasemi N, Talebi AJC, Medicine ER