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By highlighting lactylation as a metabolic sensor that translates intracellular lactate levels into transcriptional and functional changes, this review provides a unifying framework connecting metabolism, epigenetics, and brain pathology

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Because the brain depends Oversecretion of insulin in response to meals on a steady supply of glucose, hypoglycemia produces a disorder termed reactive hypo- impairs mentation, alertness, and concentra- glycemia. In reactive hypoglycemia meals tion