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Mechanistically, this inhibition of glycolytic activity was attributable to destabilization of HIF-1 protein, possibly through -KG-dependent PHD enzyme-mediated hydroxylation and enhanced degradation of HIF-1 protein (33)

Effect of calorie restriction on mood, quality of life, sleep, and sexual function in healthy nonobese adults: the CALERIE 2 randomized clinical trial

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The theoretical rationale is that GH peptides could help preserve lean mass during the aggressive fat loss driven by retatrutide