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Unlike small molecules that may lack selectivity, or large proteins that face delivery challenges, peptides often provide an optimal balance of specificity, potency, and manufacturability

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Yet that tiny change shifts the peptide behavior in meaningful ways

Curr Pharm Des 20:11211125 Shibuya M (2011) Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: a crucial target for anti- and pro-angiogenic therapies