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Designing prodrugs that are inactive in the systemic circulation but are selectively activated by enzymes overexpressed in diseased tissues (e.g., cathepsins and matrix metalloproteinases) allows for the localized release of active copper-modulating agents, thereby minimizing off-target effects [257]

Keatings lab is also designing peptides that could interfere with other relatives of Mcl-1, including one called Bfl-1, which has been less studied than the other members of the family but is also involved in blocking apoptosis

A grade 3 (severe) MCL tear usually takes 6 weeks or longer to heal with treatment

Vitamin B12 deficiency may cause pins and needles in the hands or feet

Cloudiness indicates protein aggregation peptide chains have clumped together due to temperature abuse, pH drift outside the neutral range, or bacterial contamination