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Ginsenoside Rb1 prevents age-related endothelial senescence by modulating SIRT1/caveolin-1/enos signaling pathway

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This study was designed as a parallel group study, because a crossover design was not feasible with this long-acting formulation

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Single-dose pharmacokinetic studies of paynantheine (2.5 mg/kg, n = 4) and speciogynine (1.25 mg/kg, n = 3) were performed in male Sprague Dawley rats