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New insights into the local regulation of thyroid hormone availability challenge long accepted dogmas

Basal colon crypt cells are more sensitive than surface cells toward hydrogen peroxide, a factor of oxidative stress

doi: 10.1016/j.tifs.2014.03.004 76

Life style habits also result in oxidative phenomena, as in chronically cigarette smoke exposed guinea pigs the oxidative damage to muscle proteins, which precedes the characteristic respiratory changes, may contribute to muscle loss and dysfunction in smokers and patients with COPD [76]