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In general, high intake of saturated and trans fat raises LDL-cholesterol and lowers HDL-cholesterol concentrations

Archives of andrology

It has also been suggested that PAF C-16 can perform certain biological activities via pathways independent of PAFR signaling (Dyer et al., 2010)

Paeoniflorin activates the AMPK/SIRT1/PGC-1 axis to mitigate mitochondrial dysfunction, while atractylenolide III upregulates antioxidant enzymes and activates the PI3K/Akt/mTOR pathway to inhibit excessive autophagy (b)