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Outliers identified by ROUT test (Q = 1%) were excluded

Co-enzyme B12 also interacts with the enzyme methionine synthase (5-methyltetrahydrofolate-homocysteine methyltransferase), required for the conversion of homocysteine to methionine, which is essential for folic acid metabolism and the formation of thymine, which is a component of DNA

Fortified foods , such as cereals or plant-based milk, often provide B12, but not always enough for long-term health

Another way to obtain folate high producing microorganisms for in situ fortification is genetic modification

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