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The pathogenesis involves complex interactions between environmental exposure, lifestyle and age

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Virulent factor ESAT-6 drives macrophage differentiation toward the pro-inflammatory M1 phenotype and subsequently switches it to the anti-inflammatory M2 phenotype

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If the terminal ileum could not be well differentiated, the image quality of the terminal ileum was assessed using the images taken 10 min before approaching the ileocecal valve

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Indeed, recent work with transgenic mice suggests that folate deficiency may predispose heterozygotes for the CBS defect to basal hyperhomocysteinemia (Lentz et al, 2000)

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Metabolic control by the microbiome

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