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Borisenko, K

The two primary engines that drive your body are powered by glucose (sugar from carbohydrates) and fatty acids (stored body fat)

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The sensor is part of a protein that does triple duty: it senses, regulates, and delivers the antioxidant glutathione into the mitochondrial interior, where it plays critical roles in tamping down oxidizing reactions and maintaining appropriate iron levels

So far, many upstream signals have been implicated in both mitochondrial biogenesis and mitophagy as described above