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The technique is currently far from routine, however in the near future it may be part of the toolbox available for drug design

In vitro findings highlighted the efficacy of DP in suppressing inflammation, ferroptosis, and oxidative stress via activation of Nrf2pathway

This provides a great premise for reconstructing haplotyped methylomes, for allowing insights on allele-specific 5mC patterns and their effects on mutations and gene regulation, while also being able to provide epigenetic information about repeat-rich regions [25, 30, 49]

All subsequent stepsof the procedure were performed at 4C, unless stated otherwise

The present review revisits the foundational enzymology of HCU in the context of modern genotype-phenotype insights and incorporates novel epidemiological data quantifying the healthcare burden of classical HCU