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US Patent 4,255,449 and US Patent 4,268,524 describe the use of L-carnitine and alkanoyl L-carnitines, respectively, for normalising abnormally high ratios of low-density lipoproteins (LDL) + very low- density lipoproteins (VLDL) to high-density lipoproteins (HDL), which constitute an etiological factor in various cardiovascular diseases

Despite promising preclinical results with inhibitors (e.g., ferrostatin-1) and gene therapies targeting GPX4/ACSL4, clinical translation faces critical barriers: the poorly defined temporal dynamics of ferroptosis post-stroke hinders therapeutic window optimization, and its interplay with necroptosis/pyroptosis requires clarification to guide combination therapies

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Of particular significance, CTH demonstrates dual functionality not only collaborating with CBS in canonical transsulfuration pathway, but also independently catalyzing methionine cleavage

Eur J Immunol 38:24382450 Chan CYY, Chan KR, Chua CJH, nur Hazirah S, Ghosh S, Ooi EE, Low JG (2017) Early molecular correlates of adverse events following yellow fever vaccination