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10.1038/leu.2014.185 Summary Keywords CD38, antibody, daratumumab, isatuximab, MOR202, TAK-079, resistance, mode of action Citation van de Donk NWCJ and Usmani SZ (2018) CD38 Antibodies in Multiple Myeloma: Mechanisms of Action and Modes of Resistance

Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists

Mechanistic Studies Subsequent research has explored the mechanisms by which NNMT regulates metabolism, with studies demonstrating that NNMT activity reduces cellular NAD+ availability, affects SAM-dependent methylation reactions, modulates sirtuin activity, and influences adipocyte differentiation and function