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Overall, fewer people dropped out of methotrexate treatment studies if they used folic acid (10 percent) than if they did not (25 percent)

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Furthermore, these CAR-T cells alone or in coo with azacytidine is an efficient therapeutic regimen mouse model with multiple metastases of this highly aggressive MB, providing the rationale for application of the delivery of these types of CAR-T cells intracranially in humans (221)