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FRAT model and when folinic acid is appropriate When FRAT is positive (folate receptor-alpha autoantibodies), the primary problem is transport into the CNS

Luis Calln Sevilla and Luis Palomera Bernal, heads of the hematology section, from the Hospital Clnico Universitario Lozano Blesa kindly provided advice and facilities for cobalamin measurements

Concurrently, altered glucose metabolism in the orbitofrontal cortex and limbic regions reflects energy deficits and mitochondrial dysfunction, contributing to the severity of psychiatric symptoms, such as paranoia, agitation, and mood disturbances ( MRI studies have further identified gray matter atrophy in the prefrontal cortex, medial cingulate gyrus, and hippocampus, regions that are critically involved in memory, decision-making, and emotional regulation (Thompson et al., 2004)

Mol Psychiatry 23(2):199210

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