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To initiate these responses, multiple signals must be integrated in secondary lymphoid organs such as the lymph nodes and spleen 5,9

The important clue is that free iron is not as cytotoxic as hemin, as shown by incubations with iron (FeCl 2 and FeCl 3 ) that are not toxic in culture (preliminary data at [71]) and by knowing that the structure of hemin itself contributes to its toxicity [225]

2010), which is expressed in the brain, digestive tract, pancreas, muscle, bone marrow, and lymphoid tissue (HTR3A protein expression summary - The Human Protein Atlas n.d) (Table 3, Fig

Madsen, J

However, the risk of this occurring is relatively low